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The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans, it is in the neck and consists of two connected lobes. The lower two-thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thyroid is located at the front of the neck, below Adam’s apple. Thyroid disease can affect your mood — primarily causing either anxiety or depression. Generally, the more severe the thyroid disease, the more severe the mood changes.

Symptoms

If you have an overactive thyroid (hyperthyroidism), you may experience:

  • Unusual nervousness
  • Restlessness
  • Anxiety
  • Irritability

When to see a doctor

Appropriate treatment — such as medication that blocks your body’s ability to produce new thyroid hormone or replaces missing thyroid hormone — usually improves both emotional and physical symptoms caused by thyroid disease.

Causes

Still, it’s unlikely that emotional symptoms such as anxiety or depression would be the only evidence of thyroid disease. Thyroid disease is usually associated with signs and symptoms such as:

  • Weight gain or loss
  • Increased sensitivity to hot or cold temperatures
  • Bowel movement changes
  • Menstrual irregularities

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